What does Sis mean?A slang term for sister. Often used like a female equivalent to "bro", with close friends rather than relatives.
Other definitions of Sis:
- Short for sister, used as a term of endearment for a bestfriend that you consider family.
- An acronym that means "Sisters in spirit", and is used among close female friends.
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How to use the term
Alright, sis. I'm down.
Just thought I'd let you know, sis.
I've always thought of you as family, sis.
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