What does Sis mean?

A slang term for sister. Often used like a female equivalent to "bro", with close friends rather than relatives.

Other definitions of Sis:

  • Short for sister, used as a term of endearment for a bestfriend that you consider family.
  • An acronym that means "Sisters in spirit", and is used among close female friends.

All of our slang term and phrase definitions are made possible by our wonderful visitors. If you know of another definition of Sis that should be included here, please let us know.

How to use the term

  • Alright, sis. I'm down.

  • Just thought I'd let you know, sis.

  • I've always thought of you as family, sis.


There are no references for Sis at this time. We would greatly appreciate your contribution if you would like to submit your own!

More slang terms:



laughing but very serious



Thank you for your comment



I thought you'd like to know