What does STFUYSOAB mean?
shut the f**k up you son of a b***h
Other definitions of STFUYSOAB:
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How to use the term STFUYSOAB:
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More slang terms:

CTS
change the subject

EWW
Expression of disgust

ROTFLMFHO
rolling on the floor laughing my f**king head off

DWYD
Do What You Desire