What does LIS mean?
Laughing In Silence
Other definitions of LIS:
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How to use the term LIS:
There are no example uses of LIS at this time. We would greatly appreciate your contribution if you would like to submit your own!
More slang terms:

PDT
Pacific Daylight Time

LYSM
Love You So Much

BMGWL
Busting my gut with laughter

FITFO
Figure It The Fuck Out