What does ISS mean?
I'm So Sure
Other definitions of ISS:
-
im so sorry
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How to use the term ISS:
There are no example uses of ISS at this time. We would greatly appreciate your contribution if you would like to submit your own!
More slang terms:

MIMO
Multiple Input Multiple Output

TEOTWAWKI
The End Of The World As We Know It

TBR
Means to be real

4OTS
For old time's sake